Ashwagandha research paper

Abstract Withania somnifera Ashawagandha is very revered herb of the Indian Ayurvedic system of medicine as a Rasayana tonic.

Ashwagandha research paper

Find articles by K. This article has been cited by other articles in PMC. Stress is a state of mental or emotional strain or tension, which can lead to underperformance and adverse clinical conditions. Adaptogens are herbs that help in combating stress.

Ayurvedic classical texts, animal studies and clinical studies describe Ashwagandha as a safe and effective adaptogen. The aim of the study was to evaluate the safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha roots in reducing stress and anxiety and in improving the general well-being of adults who were under stress.

Single center, prospective, double-blind, randomized, placebo-controlled trial. A total of 64 subjects with a history of chronic stress were enrolled into the study after performing relevant clinical examinations and laboratory tests.

These included a measurement of serum cortisol, and assessing their scores on standard stress-assessment questionnaires. They were randomized to either the placebo control group or the study drug treatment group, and were asked to take one capsule twice a day for a period of 60 days. In the study drug treatment group, each capsule contained mg of high-concentration full-spectrum extract from the root of the Ashwagandha plant.

During the treatment period on Day 15, Day 30 and Day 45a follow-up telephone call was made to all subjects to check for treatment compliance and to note any adverse reactions.

Final safety and efficacy assessments were done on Ashwagandha research paper The adverse effects were mild in nature and were comparable in both the groups.

Ashwagandha research paper

No serious adverse events were reported. It can make a person feel embattled, nervous, anxious or otherwise less capable of full and normal response to environmental demands.

Prolonged exposure to stress can unbalance the mental and physiological state of a person, thereby leading to other illnesses like depression, high blood pressure, cardiac diseases and metabolic disorders. Such conditions, rooted in mental or emotional factors, are rapidly increasing in prevalence and emerging as major global diseases.

It is not surprising, therefore, that an increasing fraction of the population is seeking medical help to overcome stress nowadays. These herbs in times of increased stress, normalize the physiological process of the body and help the body adapt to changes.

Ashwagandha, botanically known as Withania somnifera Dunal, is a member of the Solanaceae family. It is commonly known as Indian Ginseng or Winter Cherry. The herb is so named for two reasons. One reason is that the fresh roots of the herb emit the smell of horse. The second reason is that there is a commonly held belief that a person consuming extracts of the herb may develop the strength and vitality similar to that of a horse.

It is a multipurpose herb that acts on various systems of the human body: Being the most commonly used and extensively studied adaptogen, a large volume of literature is available for Withania somnifera.

Ashwagandha contains a range of constituents like withanolides, sitoindosides and other alkaloids that are pharmacologically and medicinally important. These chemicals protect cells from oxidative damage and disease. A significant reduction was noticed in the incidence of stress-induced gastric ulcers.

However most of the trials were either in-vivo or in-vitro. Only a limited literature is available on the stress-reducing effects of Ashwagandha root extracts on humans. Our primary objective was to evaluate the efficacy of high-concentration full-spectrum Ashwagandha root extract in reducing stress and anxiety, and its role in improving general well-being in adults under stress.

The extract is drawn only from the roots of the Ashwagandha plant, using no other parts like leaves. A total of 64 subjects complaining of mental stress were enrolled into the study for a duration of 60 days. Participants Subjects were enrolled into the study if they met the following inclusion criteria: On the WHO-5 well-being index, lower scores correspond to higher levels of stress.

Subjects were excluded if they met any one of the following exclusion criteria: Interventions The recruitment process started with a pre-screening meeting, which offered an introductory lecture on stress and was part of a set of stress-management talks. The meeting was attended by participants from a wide cross-section of the population, which included doctors, students, self-employed persons, executives and employees of Information Technology firms.

These sub-populations work under stress and perceive themselves as being under stress. The purpose of the study was explained to attendees at the pre-screening meetings, who were then invited to be a part of the study.

Those who volunteered to be a part of the study were given the WHO-5 health questionnaire so that their stress levels could be assessed. The participants who had a score of 15 or lower on the WHO-5 well-being index, reported high stress levels as measured by the PSS, and who were interested in further participation were asked to visit the research site for further evaluation.

Ashwagandha research paper

On Day 0 at the research site, after obtaining written consent from the subjects, their medical history was recorded.Research paper. Studies on the immunomodulatory effects of Ashwagandha.

Therefore, using the model of myelo- and immuno-suppression drugs in mice, the normaliz- ing effects of Ashwagandha extracts were investigated.

2. Materials and methods Test materials Roots of Ashwagandha and their extract were supplied by Litaka Pharmaceuticals. Research paper. Studies on the immunomodulatory effects of Ashwagandha.

Therefore, using the model of myelo- and immuno-suppression drugs in mice, the normaliz- ing effects of Ashwagandha extracts were investigated.

2. Materials and methods Test materials Roots of Ashwagandha and their extract were supplied by Litaka Pharmaceuticals. Henceforth, in this research paper, this group will be referred to as the Ashwagandha group. The placebo-control group was given capsules containing a neutral substance.

The placebo-control group was given capsules containing a neutral substance. Jul 03,  · The research and studies of Ashwagandha's activities in the inhibition and reduction of tumour growth have shown encouraging evidence that this remarkable herb may prove to be extremely effective in the treatment of tumor type diseases including cancer (Singh and Gilca, ).

It also improves the white cell count (WBC) and function, which are. Ashwagandha, commonly known as Withania somnifera (L.) Dunal is an important medicinal plant which is used in indigenous medicine for over 3, years.

Due to its varied therapeutic potential, it has now become a subject of interest for modern scientific attention. Henceforth, in this research paper, this group will be referred to as the Ashwagandha group. The placebo-control group was given capsules containing a neutral substance.

The placebo-control group was given capsules containing a neutral substance.

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